Appleby is best known for her portrayal of Liz, a teenager who falls in love with an alien on the television series "Roswell." Her additional television credits include "Six Degrees" and the final season of "ER."
Her film credits include "Swimfan," "Undertow," "Havoc" and "Charlie Wilson's War," directed by Mike Nichols.
Appleby splits her time between Los Angeles, California and New York City, New York. She lives in Vancouver, British Columbia, during the filming of "Life Unexpected."